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Abstract
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Abstract
BACKGROUND: Propolis and its active component,
caffeic acid phenethyl ester (CAPE), have been shown
to have immunomodulatory, anti-tumoral, cytotoxic,
anti-metastatic, anti-inflammatory, and antioxidant
properties. Ionizing radiation induces radiolysis of
water and generates free radicals that result in
oxidative stress. In this study, we aimed to investigate
protective effects of propolis and CAPE on the kidney
tissue of rats against ionizing radiation-induced
oxidative stress.
MATERIALS AND METHODS: Forty-eight rats were
divided into six groups; sham group, irradiation (IR),
CAPE plus IR, propolis plus IR groups, and control
groups of propolis and CAPE. Lipid hydroperoxide
(LOOH) levels, total oxidant status (TOS), and
oxidative stress index (OSI) were assayed to
determine oxidative status. Total antioxidant status
(TAS), total sulfhydryl (–SH) levels, paraoxonase ceruloplasmin, and arylesterase activities were
determined as antioxidant parameters.
RESULTS: Kidney TOS, OSI, and LOOH levels were
significantly higher in the IR group (P<0.001). TAS and
–SH levels were significantly lower in the IR group
compared to propolis plus IR, CAPE plus IR, and sham
groups (P<0.001). Total –SH levels in the CAPE plus
IR group were significantly higher than sham group,
but were significantly decreased compared to propolis
plus IR group (P<0.001).
CONCLUSION: Ionizing radiation exposure results in
oxidative stress in rat kidneys, and propolis and CAPE
enhance antioxidant capacity and prevent kidney
tissue from radiation-induced oxidative damage by
improving antioxidant status.