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Abstract
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Abstract
BACKGROUND: In people with melatonin
deficiency, do not deteriorate only sleep
patterns but also a deterioration in the whole
hormonal balance. Melatonin can be used high
doses for sleeping problems. However,
melatonin can be effective even at very low
doses. Therefore, we have conducted a study to
demonstrate that the solve for problem of
sleeping with low-dose melatonin can be more
reliably resolved.
METHODS: A retrospective study was
performed on 17 patients who had sleep
problems and could not solve this problem with
other drugs. Karnofski performances median
80% of the patients aged between 44-83 years
and used melatonin 1-15 mg daily.
RESULTS: The patients which used dose of 1
mg melatonin with 2 days intervals for 1
month fits well. Their median increase of
performance were 10%.
DISCUSSION: According to the results of this
study, even 1-3 mg melatonin may cause some
side effects such as diarrhea in long term use.
Elderly and dementia patients should be more
careful about this problems. Long-term use of
melatonin above 3 mg should be avoided.
Intermittent use of 1 mg of melatonin can be
sufficient according to this study results.
CONCLUSION: It should be noted that it can be
effective even at very low doses such as 1 mg
and also intermittently. This retrospective study was performed in a small number of nonhomogeneous patient groups. The bigger
studies are needed about this topic.